SCHEMBL7937074

SCHEMBL7937074

O=S(=O)(N(Cl)c1ccccc1)C(F)(F)F

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
CA2 P00918 2/20 0.36
CA9 Q16790 2/20 0.36
CA1 P00915 1/20 0.36
CA5A P35218 1/20 0.36
NR1H3 Q13133 2/20 0.35
APOBEC3G Q9HC16 1/20 0.34
PKM P14618 1/20 0.34
PTGS1 P23219 1/20 0.34
PTGS2 P35354 1/20 0.34
HSD11B1 P28845 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.33
HSD17B10 Q99714 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
NPC1 O15118 1/20 0.33
POLB P06746 1/20 0.33
MLYCD O95822 1/20 0.33
CA12 O43570 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL64494 0.78 CA2 (0.43) ALDH1A1MEN1KMT2ACA2CA9
SCHEMBL13096335 0.78 PKM (0.45) ALDH1A1MEN1KMT2ACA2CA9
SCHEMBL15082546 0.75 ALDH1A1 (0.37) ALDH1A1MEN1KMT2ACA2CA9
SCHEMBL9888504 0.75 NR1H3 (0.49) ALDH1A1MEN1KMT2ACA2CA9
SCHEMBL176126 0.75 NR1H3 (0.45) ALDH1A1MEN1KMT2ACA2CA9
SCHEMBL14331424 0.75 HSP90AA1 (0.48) ALDH1A1MEN1KMT2ACA2CA9
SCHEMBL7937073 0.73 ALDH1A1 (0.39) ALDH1A1MEN1KMT2ACA2CA9
SCHEMBL16300054 0.73 MEN1 (0.33) ALDH1A1MEN1KMT2ACA2CA9
SCHEMBL11417943 0.73 PKM (0.39) ALDH1A1MEN1KMT2ACA2CA9
SCHEMBL624941 0.72 KMT2A (0.38) ALDH1A1MEN1KMT2ACA2CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6221890-B1 2-METHOXYCARBONYL-4-CHLOROTRIFLUOROMETHANESULFONANILIDE AND 2-(2,6-DIFLUOROPHENYL)-4-(2-ETHOXY-4-TERT-BUTYLPHENYL)-2-OXAZO LINE TOGETHER AS ACTIVE INGREDIENTS. SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2001-04-24 US disclosed