Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9278929 | 0.80 | ALDH1A1 (0.39) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL7937291 | 0.75 | HTR1A (0.62) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL9001189 | 0.74 | HTR1A (0.50) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL6546383 | 0.69 | HTR1A (1.00) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL8065712 | 0.69 | HTR1A (1.00) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL9001256 | 0.67 | HTR1A (0.68) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL9004457 | 0.66 | HTR1A (0.80) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL8442654 | 0.66 | HTR1A (0.80) | HTR1AHTR1DHTR2BALDH1A1LMNA | |
| SCHEMBL10575998 | 0.66 | HTR1A (0.52) | HTR1AHTR1DHTR2BALDH1A1DPP7 | |
| SCHEMBL8761484 | 0.65 | HTR1A (0.53) | HTR1AHTR1DHTR2BALDH1A1DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760665-B1 | COMPOSITIONS CONTAINING 5HTIA AND 5HTID ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-12-12 | — | — | EP | claimed |
| US-5585374-A | Amide derivatives | JOHN WYETH BROTHER, LIMITED (GB) | 1996-12-17 | — | — | US | claimed |
| EP-0760665-B1 | COMPOSITIONS CONTAINING 5HTIA AND 5HTID ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-12-12 | — | — | EP | disclosed |
| EP-0760665-A1 | COMPOSITION CONTAINING 5HT IA? and 5HT ID? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-03-12 | — | — | EP | disclosed |
| US-5585374-A | Amide derivatives | JOHN WYETH BROTHER, LIMITED (GB) | 1996-12-17 | — | — | US | disclosed |
| WO-1995031988-A1 | COMPOSITION CONTAINING 5HTIA and 5HTID ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 1995-11-30 | — | — | WO | disclosed |
| EP-0664801-A1 | AMIDE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1995-08-02 | — | — | EP | disclosed |
| WO-1994003444-A1 | AMIDE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1994-02-17 | — | — | WO | disclosed |