SCHEMBL7937532

SCHEMBL7937532

CO[C@]1(C=C=O)C(=O)N(CC(=O)O)CCN1C(=O)[C@H](CC(=O)N1CCN(c2ccncc2)CC1)N(C)Cc1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 2/20 0.34
ITGA2B P08514 2/20 0.34
RORC P51449 7/20 0.34
TDP1 Q9NUW8 2/20 0.33
MAPK1 P28482 1/20 0.33
POLB P06746 1/20 0.32
MAPT P10636 1/20 0.32
TGM2 P21980 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
TSHR P16473 1/20 0.32
CASP1 P29466 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7924777 0.86 ITGB3 (0.37) ITGB3ITGA2BTDP1MAPK1POLB
Trifluoroacetic Acid SCHEMBL7924843 0.81 DPP8 (0.42) ITGB3ITGA2BCYP3A4CYP2D6CYP2C9
Trifluoroacetic Acid SCHEMBL7934191 0.81 DPP8 (0.42) ITGB3ITGA2BCYP3A4CYP2D6CYP2C9
SCHEMBL7402557 0.80 ALDH1A1 (0.36) ITGB3ITGA2BTDP1MAPK1POLB
SCHEMBL7937529 0.78 RORC (0.35) ITGB3ITGA2BRORCTDP1MAPK1
SCHEMBL7937548 0.78 ITGB3 (0.34) ITGB3ITGA2BTGM2CYP3A4CYP2D6
SCHEMBL7931599 0.77 ITGB3 (0.42) ITGB3ITGA2BRORCCASP1
SCHEMBL7367242 0.77 ITGB3 (0.42) ITGB3ITGA2BRORCCASP1
SCHEMBL7931603 0.77 ITGB3 (0.42) ITGB3ITGA2BRORCCASP1
SCHEMBL7367244 0.68 RORC (0.36) RORCCYP3A4CYP2D6CYP2C9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6242600-B1 ANTIISCHEMIC AGENTS, ANTICOAGULANTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-06-05 US disclosed