Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.38 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL793765 | 0.71 | ALDH1A1 (0.45) | HDAC3HTR1AHTR7USP2ALDH1A1 | |
| SCHEMBL1720286 | 0.70 | FPR2 (0.37) | HDAC3HDAC2SCN9AKITCYP1A2 | |
| SCHEMBL655170 | 0.70 | CNR2 (0.48) | HRH4KITCNR2ALDH1A1TSHR | |
| SCHEMBL655042 | 0.69 | HRH4 (0.61) | HRH4HRH3CNR2ALDH1A1TSHR | |
| SCHEMBL4560186 | 0.62 | HDAC1 (0.43) | HRH4HDAC3HDAC2SCN9AHDAC1 | |
| SCHEMBL4560538 | 0.61 | MKNK2 (0.46) | SCN9AHDAC1USP2ALDH1A1CYP1A2 | |
| SCHEMBL11201732 | 0.60 | P2RY12 (0.48) | P2RY12HRH4ALDH1A1TSHRCASP1 | |
| SCHEMBL654538 | 0.59 | ALDH1A1 (0.75) | ALDH1A1 | |
| SCHEMBL655041 | 0.59 | USP2 (0.35) | HRH4HDAC3HDAC2HTR1AHTR7 | |
| SCHEMBL798319 | 0.59 | CHEK1 (0.46) | HTR1AHTR7USP2ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405973-A2 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103130-A2 | NOVEL BICYCLIC HETEROCYCLES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D (BE) | 2010-09-16 | — | — | WO | disclosed |