Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7937760 | 0.88 | ALDH1A1 (0.57) | ALDH1A1MAPTL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL3946896 | 0.88 | ALDH1A1 (0.56) | ALDH1A1MAPTL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL3265135 | 0.85 | ALDH1A1 (0.67) | ALDH1A1MAPTL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL3946900 | 0.82 | ALDH1A1 (0.49) | ALDH1A1MAPTL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL3946894 | 0.82 | MAPT (0.49) | ALDH1A1MAPTL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL3950431 | 0.79 | MAPT (0.60) | ALDH1A1MAPTL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL3946586 | 0.78 | ALDH1A1 (0.54) | ALDH1A1MAPTL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL7946305 | 0.77 | MAPT (0.62) | ALDH1A1MAPTL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL3950369 | 0.77 | ALDH1A1 (0.55) | ALDH1A1MAPTL3MBTL1KDM4EHSD17B10 | |
| SCHEMBL4312470 | 0.76 | ALDH1A1 (0.42) | ALDH1A1MAPTL3MBTL1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |