Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | PYGL | P06737 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4308534 | 0.86 | ADRA1D (0.43) | ALDH1A1MAPK14KDM4EHSD17B10DRD2 | |
| SCHEMBL4312756 | 0.84 | HDAC1 (0.47) | ALDH1A1MAPTL3MBTL1ROCK2ROCK1 | |
| SCHEMBL3120950 | 0.83 | ALDH1A1 (0.40) | ALDH1A1MAPTL3MBTL1ROCK2ROCK1 | |
| SCHEMBL4304078 | 0.82 | MAPK14 (0.43) | ALDH1A1MAPTL3MBTL1ROCK2ROCK1 | |
| SCHEMBL4310271 | 0.82 | ALDH1A1 (0.41) | ALDH1A1MAPTL3MBTL1ROCK2ROCK1 | |
| SCHEMBL3121013 | 0.81 | ALDH1A1 (0.40) | ALDH1A1MAPTL3MBTL1ROCK2ROCK1 | |
| SCHEMBL4306692 | 0.81 | HDAC1 (0.42) | ALDH1A1MAPTL3MBTL1ROCK2ROCK1 | |
| SCHEMBL7938658 | 0.79 | ALDH1A1 (0.51) | ALDH1A1MAPTL3MBTL1ROCK2ROCK1 | |
| SCHEMBL7947627 | 0.79 | ALDH1A1 (0.51) | ALDH1A1MAPTL3MBTL1KMT2AKDM4E | |
| SCHEMBL4313368 | 0.79 | ALDH1A1 (0.43) | ALDH1A1MAPTL3MBTL1POLBMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | claimed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |