SCHEMBL7939165

SCHEMBL7939165

C=CC(=O)OC(F)(F)C(F)(c1ccccc1)C(F)(F)F

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.37
ALDH1A1 P00352 5/20 0.37
TSHR P16473 2/20 0.37
AKT1 P31749 1/20 0.35
HTT P42858 1/20 0.35
PTPN1 P18031 1/20 0.34
MAOB P27338 1/20 0.34
LMNA P02545 3/20 0.33
MAPT P10636 3/20 0.33
S1PR4 O95977 1/20 0.33
S1PR1 P21453 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
TGM2 P21980 2/20 0.33
KCNN4 O15554 1/20 0.33
CYP2C19 P33261 1/20 0.33
HIF1A Q16665 1/20 0.33
MAPK1 P28482 1/20 0.32
CES2 O00748 1/20 0.32
CYP1A2 P05177 2/20 0.32
CES1 P23141 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7939162 0.80 LMNA (0.41) THRBALDH1A1TSHRAKT1HTT
SCHEMBL4606750 0.80 THRB (0.41) THRBALDH1A1TSHRAKT1HTT
SCHEMBL20102170 0.79 CYP2C19 (0.41) THRBALDH1A1TSHRAKT1HTT
SCHEMBL7859075 0.77 HTT (0.46) THRBALDH1A1TSHRAKT1HTT
SCHEMBL3692619 0.76 ELANE (0.39) ALDH1A1TSHRPTPN1MAPTKCNN4
SCHEMBL438661 0.75 THRB (0.43) THRBALDH1A1TSHRAKT1HTT
SCHEMBL22472203 0.75 THRB (0.43) THRBALDH1A1TSHRAKT1HTT
SCHEMBL1153650 0.74 THRB (0.46) THRBALDH1A1TSHRAKT1HTT
SCHEMBL16086568 0.74 THRB (0.42) THRBALDH1A1TSHRAKT1HTT
SCHEMBL3169549 0.74 CYP2C19 (0.46) THRBALDH1A1TSHRAKT1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105209936-B Optical element for correcting color blindness 日东电工株式会社 2020-01-14 CN disclosed
CN-104024891-B For correcting the optical element of colour blindness 日东电工株式会社 2019-06-28 CN disclosed
CN-105209936-A Optical element for correcting color blindness NITTO DENKO CORP 2015-12-30 CN disclosed
US-6277940-B1 TRANSPARENCY AND FLEXIBILITY, REFRACTIVE INDEX, CAN BE INSERTED FROM A SMALL INCISION MENICON CO. LTD (JP) 2001-08-21 US disclosed