Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 14/20 | 0.50 |
| ▸ | RXRB | P28702 | 7/20 | 0.50 |
| ▸ | RXRG | P48443 | 6/20 | 0.50 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 4/20 | 0.41 |
| ▸ | RARG | P13631 | 3/20 | 0.41 |
| ▸ | RARA | P10276 | 2/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.39 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7940005 | 0.89 | RXRA (0.51) | RXRARXRBRXRGKDM1AALDH1A1 | |
| SCHEMBL8731089 | 0.87 | RXRA (0.54) | RXRARXRBRXRGKDM1AKDM4E | |
| SCHEMBL4425637 | 0.86 | RXRA (0.51) | RXRARXRBRXRGKDM1AKDM4E | |
| SCHEMBL8375020 | 0.86 | RXRA (0.61) | RXRARXRBRXRGKDM1AKDM4E | |
| SCHEMBL2223215 | 0.81 | GNG2 (0.52) | RXRARXRBRXRGKDM1AKDM4E | |
| SCHEMBL1022234 | 0.78 | RXRA (0.63) | RXRARXRBRXRGKDM4EALDH1A1 | |
| SCHEMBL18585497 | 0.76 | ALDH1A1 (0.68) | RXRARXRBRXRGMAPTALDH1A1 | |
| SCHEMBL6582499 | 0.76 | ALDH1A1 (0.62) | RXRARXRBRXRGMAPTALDH1A1 | |
| SCHEMBL12516220 | 0.76 | MAPT (0.53) | RXRARXRBRXRGKDM1AKDM4E | |
| SCHEMBL8733110 | 0.76 | RXRA (0.55) | RXRARXRBRXRGALDH1A1RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313162-B1 | FOR USE IN HUMAN OR VETERINARY MEDICINE SUCH AS DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR AND OPHHALMOLOGICAL DISORDERS; AND IN COSMETICS | CENTRE INTERNATIONAL DE RECHERCHE DERMATOLOGIQUES GALDERMA (C.I.R.D.) GALDERMA (FR) | 2001-11-06 | — | — | US | disclosed |
| US-6046220-A | ADMINISTERING TO THE PATIENT A PROPYNYL OR DIENYL BIAROMATIC COMPOUND TO TREAT A SKIN DISORDER, INFLAMMATORY CONDITIONS, VISION DEFECTS, ALOPECIA, CARDIOVASCULAR DISORDER, CANCER OR PRECANCER AND INSULIN DEPENDANT DIABETES | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2000-04-04 | — | — | US | disclosed |