Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | NNMT | P40261 | 1/20 | 0.43 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2567666 | 0.84 | KDM4E (0.41) | NNMTLOXL2ADRB2CYP3A4KDM4E | |
| SCHEMBL22255185 | 0.82 | HCAR3 (0.41) | HCAR3NNMTCPB2CYP3A4MAPT | |
| SCHEMBL20666278 | 0.81 | CPB2 (0.41) | HCAR3NNMTCPB2CYP3A4MAPT | |
| SCHEMBL12020150 | 0.81 | HCAR3 (0.46) | HCAR3NNMTCPB2KDM4ECYP11B1 | |
| SCHEMBL13456505 | 0.80 | NUDT1 (0.42) | LOXL2ADRB2CYP3A4KDM4EMAPT | |
| SCHEMBL1570175 | 0.79 | HCAR3 (0.48) | HCAR3NNMTCPB2KDM4EMAPT | |
| SCHEMBL479854 | 0.79 | NNMT (0.47) | HCAR3NNMTCPB2LOXL2ADRB2 | |
| SCHEMBL1570177 | 0.79 | HCAR3 (0.48) | HCAR3NNMTCPB2MAPTCYP11B1 | |
| SCHEMBL12881954 | 0.78 | HCAR3 (0.43) | HCAR3NNMTCPB2CYP3A4KDM4E | |
| SCHEMBL19080615 | 0.77 | HCAR3 (0.41) | HCAR3CPB2LOXL2ADRB2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010030967-A1 | 4-ARYLOXYQUINOLIN-2(1H)-ONES AS MTOR KINASE AND PI3 KINASE INHIBITORS, FOR USE AS ANTI-CANCER AGENTS | WYETH LLC (US) | 2010-03-18 | — | — | WO | disclosed |