SCHEMBL7940656

SCHEMBL7940656

O=C(OCC(Cl)(Cl)Cl)N1C2CCC1CC(Sc1ccc(Cl)cc1)C2

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CTSS P25774 1/20 0.36
CYP2D6 P10635 2/20 0.35
CYP2C19 P33261 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35
TSHR P16473 1/20 0.35
CHRM1 P11229 7/20 0.35
OPRM1 P35372 1/20 0.34
OPRK1 P41145 1/20 0.34
KCNH2 Q12809 1/20 0.34
STS P08842 2/20 0.34
CHRM2 P08172 2/20 0.33
CHRM3 P20309 2/20 0.33
CHRM4 P08173 2/20 0.33
MAPT P10636 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
LMNA P02545 1/20 0.33
CHRM5 P08912 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7952076 0.89 CHRM1 (0.41) CHRM1OPRM1OPRK1KCNH2CHRM2
SCHEMBL7335086 0.89 OPRM1 (0.44) CHRM1OPRM1OPRK1KCNH2CHRM2
SCHEMBL4487010 0.87 GRIN1 (0.43) CHRM1CHRM2CHRM3CHRM4SMN1; SMN2
SCHEMBL2190026 0.73 CHRM1 (0.54) CYP2C9CHRM1CHRM2CHRM3CHRM4
SCHEMBL2190030 0.73 CHRM1 (0.54) CYP2C9CHRM1CHRM2CHRM3CHRM4
SCHEMBL857819 0.72 CHRM1 (0.38) CHRM1CHRM2CHRM3CHRM4CHRM5
SCHEMBL12507091 0.71 CHRM1 (0.37) CHRM1CHRM2CHRM3CHRM4LMNA
SCHEMBL4830125 0.70 CHRM1 (0.47) CHRM1CHRM2CHRM3CHRM4
SCHEMBL12355754 0.70 CHRM1 (0.40) CHRM1CHRM2CHRM3CHRM4LMNA
SCHEMBL6216166 0.70 BRD4 (0.34) CYP2D6CYP2C19CYP1A2CYP2C9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6258827-B1 HYDROXYAROMATIC HETEROCYCLIC ALKANOLS AND LEVODOPA PFIZER INC. 2001-07-10 US disclosed
US-6046213-A Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydroxyphenyl)-2-(piperidinyl-1)-alkanol derivatives PFIZER INC. (US) 2000-04-04 US disclosed
EP-0828513-A2 COMBINATIONS FOR THE TREATMENT OF PARKINSONISM CONTAINING SELECTIVE NMDA ANTAGONISTS PFIZER INC. (US) 1998-03-18 EP disclosed
EP-0777652-A1 NEUROPROTECTIVE 3-(PIPERIDINYL-1)-CHROMAN-4,7-DIOL AND 1-(4-HYDROPHENYL)-2-(PIPERIDINYL-1)-ALKANOL DERIVATIVES PFIZER INC. (US) 1997-06-11 EP disclosed
WO-1996037226-A2 COMBINATIONS FOR THE TREATMENT OF PARKINSONISM CONTAINING SELECTIVE NMDA ANTAGONISTS PFIZER INC. (US) 1996-11-28 WO disclosed
US-5498610-A Neuroprotective indolone and related derivatives PFIZER INC. (US) 1996-03-12 US disclosed
WO-1996006081-A1 NEUROPROTECTIVE 3-(PIPERIDINYL-1)-CHROMAN-4,7-DIOL AND 1-(4-HYDROPHENYL)-2-(PIPERIDINYL-1)-ALKANOL DERIVATIVES PFIZER INC. (US) 1996-02-29 WO disclosed
US-5306723-A Neuroprotective indolone and related derivatives PFIZER INC. (US) 1994-04-26 US disclosed
EP-0554247-A1 NEUROPROTECTIVE INDOLONE AND RELATED DERIVATIVES PFIZER INC. (US) 1993-08-11 EP disclosed
WO-1991017156-A1 NEUROPROTECTIVE INDOLONE AND RELATED DERIVATIVES PFIZER INC (US) 1991-11-14 WO disclosed