Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 9/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7940656 | 0.89 | CTSS (0.36) | CHRM1OPRM1OPRK1KCNH2CHRM2 | |
| SCHEMBL7335086 | 0.88 | OPRM1 (0.44) | CHRM1GRIN1GRIN2BOPRM1OPRK1 | |
| SCHEMBL4487010 | 0.86 | GRIN1 (0.43) | CHRM1GRIN1GRIN2BCHRM2CHRM3 | |
| SCHEMBL2190030 | 0.72 | CHRM1 (0.54) | CHRM1GPR119CHRM2CHRM3CHRM4 | |
| SCHEMBL2190026 | 0.72 | CHRM1 (0.54) | CHRM1GPR119CHRM2CHRM3CHRM4 | |
| SCHEMBL8814399 | 0.72 | GRIN1 (0.40) | CHRM1GRIN1GRIN2BCHRM2CHRM3 | |
| SCHEMBL857819 | 0.71 | CHRM1 (0.38) | CHRM1GPR119CHRM2CHRM3CHRM4 | |
| SCHEMBL7560109 | 0.71 | SLC6A3 (0.41) | CHRM1CHRM2CHRM3CHRM4 | |
| SCHEMBL6991525 | 0.70 | SIGMAR1 (0.36) | CHRM1 | |
| SCHEMBL12507091 | 0.70 | CHRM1 (0.37) | CHRM1GPR119CHRM2CHRM3CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258827-B1 | HYDROXYAROMATIC HETEROCYCLIC ALKANOLS AND LEVODOPA | PFIZER INC. | 2001-07-10 | — | — | US | disclosed |
| US-6046213-A | Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydroxyphenyl)-2-(piperidinyl-1)-alkanol derivatives | PFIZER INC. (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0828513-A2 | COMBINATIONS FOR THE TREATMENT OF PARKINSONISM CONTAINING SELECTIVE NMDA ANTAGONISTS | PFIZER INC. (US) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996037226-A2 | COMBINATIONS FOR THE TREATMENT OF PARKINSONISM CONTAINING SELECTIVE NMDA ANTAGONISTS | PFIZER INC. (US) | 1996-11-28 | — | — | WO | disclosed |