Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | ELOVL6 | Q9H5J4 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7940656 | 0.87 | CTSS (0.36) | CHRM1CHRM3CHRM2CHRM4SMN1; SMN2 | |
| SCHEMBL7952076 | 0.86 | CHRM1 (0.41) | GRIN1GRIN2BCHRM1CHRM3CHRM2 | |
| SCHEMBL7335086 | 0.86 | OPRM1 (0.44) | GRIN1GRIN2BCHRM1CHRM3CHRM2 | |
| SCHEMBL12355754 | 0.73 | CHRM1 (0.40) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5635722 | 0.72 | SLC6A3 (0.47) | GRIN1GRIN2BCHRM1CHRM3CHRM2 | |
| SCHEMBL4475967 | 0.72 | SLC6A3 (0.47) | GRIN1GRIN2BCHRM1CHRM3CHRM2 | |
| SCHEMBL2190026 | 0.71 | CHRM1 (0.54) | CHRM1CHRM3CHRM2CHRM4ALDH1A1 | |
| SCHEMBL2190030 | 0.71 | CHRM1 (0.54) | CHRM1CHRM3CHRM2CHRM4ALDH1A1 | |
| SCHEMBL857819 | 0.70 | CHRM1 (0.38) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL12875929 | 0.69 | CHRM2 (0.47) | CHRM1CHRM3CHRM2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7494992-B2 | Antiparasitic terpene alkaloids | PFIZER INC. (US) | 2009-02-24 | — | — | US | disclosed |
| US-20070185101-A1 | Antiparasitic terpene alkaloids | PFIZER PRODUCTS INC | 2007-08-09 | — | — | US | disclosed |
| EP-1597264-A2 | ANTIPARASITIC TERPENE ALKALOIDS | Pfizer Limited (GB) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004072086-A2 | ANTIPARASITIC TERPENE ALKALOIDS | PFIZER LIMITED (GB) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185101-A1 | Antiparasitic terpene alkaloids | CYP51A1, DHPS, CYP8B1 | GRIN1 415/4885GRIN2B 611/4885CHRM1 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.