Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | LIPE | Q05469 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7941573 | 0.89 | RAB9A (0.59) | RAB9ASMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL7944420 | 0.87 | LMNA (0.55) | RAB9ASMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL16638538 | 0.85 | RAB9A (0.62) | RAB9ASMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL11262678 | 0.84 | CYP1A2 (0.63) | RAB9ASMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL11299037 | 0.81 | RAB9A (0.65) | RAB9ASMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL7935341 | 0.81 | SMN1; SMN2 (0.70) | RAB9ASMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL11360493 | 0.80 | SMN1; SMN2 (0.71) | RAB9ASMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL1153779 | 0.80 | LMNA (0.61) | RAB9ASMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL12585076 | 0.79 | LMNA (0.64) | RAB9ASMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL8020738 | 0.79 | THRB (0.57) | LMNAMAPTHPGDLIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |