SCHEMBL794174

SCHEMBL794174

O=C(Cl)c1cc(Cl)nc(Cl)c1

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
S1PR2 O95136 1/20 0.48
NAPRT Q6XQN6 1/20 0.37
BCHE P06276 3/20 0.36
ACHE P22303 3/20 0.36
CYP2C19 P33261 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
LMNA P02545 1/20 0.34
ALDH1A1 P00352 3/20 0.34
MAPK1 P28482 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
FFAR1 O14842 2/20 0.34
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
TPMT P51580 1/20 0.33
TSHR P16473 1/20 0.32
HCAR2 Q8TDS4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL348783 0.84 SMN1; SMN2 (0.46) S1PR2LMNAALDH1A1MAPK1SMN1; SMN2
SCHEMBL12785948 0.84 CA9 (0.36) S1PR2NAPRT
SCHEMBL931870 0.80 ALDH1A1 (0.52) TDP1LMNAALDH1A1SMN1; SMN2
SCHEMBL6956539 0.79 S1PR2 (0.48) S1PR2NAPRTBCHEACHECYP2C19
2,6-Dichloroisonicotinic Acid SCHEMBL56204 0.79 TPMT (0.56) S1PR2NAPRTTDP1LMNAALDH1A1
SCHEMBL362611 0.77 CA5A (0.48) S1PR2BCHEACHECYP2C19TDP1
SCHEMBL3281481 0.77 LMNA (0.48) S1PR2CYP2C19TDP1LMNASMN1; SMN2
2,6-Dichloroisonicotinic Acid SCHEMBL2264628 0.77 TPMT (0.54) S1PR2NAPRTTDP1LMNAALDH1A1
2,6-Dichloroisonicotinic Acid SCHEMBL11071500 0.77 TPMT (0.54) S1PR2NAPRTTDP1LMNAALDH1A1
SCHEMBL7828834 0.77 S1PR2 (0.46) S1PR2BCHEACHECYP2C19TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 171 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115322146-B Preparation method of 4-amino-2, 6-dichloropyridine 安徽峆一药业股份有限公司 2024-04-19 CN claimed
CN-115322146-A Preparation method of 4-amino-2,6-dichloropyridine 安徽峆一药业股份有限公司 2022-11-11 CN claimed
JP-10072440-A None JP disclosed
JP-9249648-A None JP disclosed
JP-9165373-A None JP disclosed
JP-9165374-A None JP disclosed
JP-8208615-A None JP disclosed
EP-4731207-A2 INHIBITORS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS AND METAPNEUMOVIRUS Merck Sharp & Dohme LLC (US) 2026-04-29 EP disclosed
EP-4725942-A1 COMPOUNDS ACTIVE ON CYCLIN D1 PATHWAY AND THEIR USE Sibylla Biotech S.p.A. (IT) 2026-04-15 EP disclosed
EP-4687854-A2 LIPIDS AND LIPID-LIKE COMPOUNDS FOR THERAPEUTIC LIPID NANOPARTICLE (LNP) DELIVERY Flagship Labs 114, Inc. (US) 2026-02-11 EP disclosed
WO-2024259171-A9 KEAP1 INHIBITORS AND USES THEREOF VIVIDION THERAPEUTICS, INC. (US) 2025-01-23 WO disclosed
US-4690934-A N-phenylsulfonylisonicotinamide derivatives and their use as fungicides or bactericides NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1987-09-01 US disclosed
EP-0195201-A2 Process for the preparation of N-acyl-2,3-dehydro carboxylic esters Degussa Aktiengesellschaft (DE) 1986-09-24 EP disclosed
US-4340739-A CHEMICAL INTERMEDIATES IN THE PRODUCTION OF N-AZOLYLMETHYL-COMPOUNDS BASF AKTIENGESELLSCHAFT (DE) 1982-07-20 US disclosed
US-4265892-A Cephalosporins having an α-acylaminoacetic acid side chain CIBA-GEIGY CORPORATION (US) 1981-05-05 US disclosed
US-4195984-A Herbicides derived from dihalo isonicotinoyl derivatives of amino acids ABBOTT LABORATORIES (US) 1980-04-01 US disclosed
US-4154831-A Cephalosporins having an α-acylaminoacetic acid side chain CIBA-GEIGY CORPORATION (US) 1979-05-15 US disclosed
US-4041161-A ANTIBIOTICS CIBA-GEIGY CORPORATION (US) 1977-08-09 US disclosed
US-4033753-A HERICIDES VELSICOL CHEMICAL CORPORATION (US) 1977-07-05 US disclosed
US-3983126-A SEDATIVES DUFOUR CLAUDE 1976-09-28 US disclosed