SCHEMBL7941781

SCHEMBL7941781

O=c1c2c[nH]c3ccccc3n-2c(=O)n1-c1cccc(F)c1

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 3/20 0.43
METAP2 P50579 1/20 0.39
FAAH O00519 1/20 0.37
MGLL Q99685 1/20 0.37
MPI P34949 2/20 0.36
GAA P10253 2/20 0.36
KDM4E B2RXH2 1/20 0.36
JAK2 O60674 1/20 0.36
JAK3 P52333 1/20 0.36
ALDH1A1 P00352 1/20 0.35
POLB P06746 1/20 0.35
MAPT P10636 1/20 0.35
ADORA2A P29274 1/20 0.35
ADORA1 P30542 1/20 0.35
PRKCB P05771 1/20 0.35
LMNA P02545 1/20 0.34
TP53 P04637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7949177 0.86 KDM4E (0.51) MPIGAAKDM4EALDH1A1MAPT
SCHEMBL7941785 0.85 LMNA (0.39) ADORA3METAP2MPIJAK2JAK3
SCHEMBL7941798 0.85 PGR (0.46) MPIGAAKDM4ELMNA
SCHEMBL7949708 0.85 MAPT (0.47) ADORA3MPIKDM4EALDH1A1MAPT
SCHEMBL7953527 0.82 NTRK1 (0.47) GAAALDH1A1MAPTLMNATP53
SCHEMBL7949713 0.80 NTRK1 (0.41) ADORA3GAAALDH1A1MAPTLMNA
SCHEMBL7947995 0.80 ALDH1A1 (0.38) MGLLMPIKDM4EALDH1A1POLB
SCHEMBL7951665 0.77 LMNA (0.40) ADORA3MPIGAAKDM4EALDH1A1
SCHEMBL7941792 0.77 SMN1; SMN2 (0.43) ADORA3METAP2KDM4EALDH1A1POLB
SCHEMBL7949731 0.77 HSP90AA1 (0.41) ADORA3GAAKDM4EALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6268496-B1 GAMMA-AMINOBUTYRIC ACID RECEPTOR LIGANDS NEUROGEN CORPORATION 2001-07-31 US claimed
EP-0555391-B1 CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORP (US) 2000-07-12 EP claimed
EP-0555391-A1 CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 1993-08-18 EP claimed
US-5130430-A Anxiety, sleep disorders or seizures NEUROGEN CORPORATION (US) 1992-07-14 US claimed
WO-1992007853-A1 CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 1992-05-14 WO claimed
US-6268496-B1 GAMMA-AMINOBUTYRIC ACID RECEPTOR LIGANDS NEUROGEN CORPORATION 2001-07-31 US disclosed
EP-0555391-B1 CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORP (US) 2000-07-12 EP disclosed
US-5744602-A PSYCHOLOGICAL DISORDERS, ANTICONVULSANTS NEUROGEN CORPORATION (US) 1998-04-28 US disclosed
EP-0555391-A1 CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 1993-08-18 EP disclosed
US-5130430-A Anxiety, sleep disorders or seizures NEUROGEN CORPORATION (US) 1992-07-14 US disclosed
WO-1992007853-A1 CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 1992-05-14 WO disclosed