SCHEMBL7941785

SCHEMBL7941785

O=c1c2c[nH]c3ccccc3n-2c(=O)n1-c1ccc(F)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.39
METAP2 P50579 1/20 0.38
NR4A2 P43354 1/20 0.38
HKDC1 Q2TB90 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.37
PPARG P37231 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
NR2E3 Q9Y5X4 1/20 0.36
NCOR2 Q9Y618 1/20 0.36
KMT2A Q03164 2/20 0.36
POLB P06746 1/20 0.36
PGR P06401 1/20 0.36
PMM2 O15305 1/20 0.35
MPI P34949 1/20 0.35
RAB9A P51151 1/20 0.35
PHOSPHO1 Q8TCT1 1/20 0.35
APOBEC3G Q9HC16 1/20 0.35
TSHR P16473 1/20 0.35
HTT P42858 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7941798 0.88 PGR (0.46) LMNAL3MBTL1KMT2APGRMPI
SCHEMBL7949731 0.86 HSP90AA1 (0.41) LMNAL3MBTL1NPSR1KMT2APOLB
SCHEMBL7951665 0.86 LMNA (0.40) LMNAL3MBTL1NPSR1KMT2APGR
SCHEMBL7941792 0.86 SMN1; SMN2 (0.43) LMNAMETAP2PPARGNPSR1RXFP1
SCHEMBL7941781 0.85 ADORA3 (0.43) LMNAMETAP2POLBMPIJAK2
SCHEMBL7947995 0.83 ALDH1A1 (0.38) LMNAKMT2APOLBMPIRAB9A
SCHEMBL7953532 0.83 MAPT (0.51) LMNAMETAP2NPSR1KMT2AADORA3
SCHEMBL7951689 0.83 POLB (0.46) RXFP1POLBPGRAPOBEC3GADORA3
SCHEMBL7949715 0.81 PGR (0.40) HKDC1RXFP1POLBPGRAPOBEC3G
SCHEMBL7949717 0.80 MAPT (0.53) LMNANPSR1RXFP1KMT2AADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6268496-B1 GAMMA-AMINOBUTYRIC ACID RECEPTOR LIGANDS NEUROGEN CORPORATION 2001-07-31 US claimed
EP-0555391-B1 CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORP (US) 2000-07-12 EP claimed
EP-0555391-A1 CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 1993-08-18 EP claimed
US-5130430-A Anxiety, sleep disorders or seizures NEUROGEN CORPORATION (US) 1992-07-14 US claimed
WO-1992007853-A1 CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 1992-05-14 WO claimed
US-6268496-B1 GAMMA-AMINOBUTYRIC ACID RECEPTOR LIGANDS NEUROGEN CORPORATION 2001-07-31 US disclosed
EP-0555391-B1 CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORP (US) 2000-07-12 EP disclosed
US-5744602-A PSYCHOLOGICAL DISORDERS, ANTICONVULSANTS NEUROGEN CORPORATION (US) 1998-04-28 US disclosed
EP-0555391-A1 CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 1993-08-18 EP disclosed
US-5130430-A Anxiety, sleep disorders or seizures NEUROGEN CORPORATION (US) 1992-07-14 US disclosed
WO-1992007853-A1 CERTAIN IMIDAZOQUINOXALINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS NEUROGEN CORPORATION (US) 1992-05-14 WO disclosed