Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.69 |
| ▸ | MAPT | P10636 | 6/20 | 0.69 |
| ▸ | GAA | P10253 | 5/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | HPGD | P15428 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | MPI | P34949 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12941614 | 0.88 | GAA (0.58) | KDM4EALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL27459594 | 0.88 | KDM4E (0.55) | KDM4EALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL7912397 | 0.85 | ADORA3 (0.59) | KDM4EALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL8123765 | 0.84 | ADORA3 (0.60) | KDM4EALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL10939957 | 0.81 | KDM4E (0.67) | KDM4EALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL1628395 | 0.80 | ALDH1A1 (0.67) | KDM4EALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL6617327 | 0.79 | MAPT (0.60) | KDM4EALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL30233473 | 0.79 | MAPT (0.60) | KDM4EALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL10995103 | 0.78 | KDM4E (0.62) | KDM4EALDH1A1MAPTGAASMN1; SMN2 | |
| SCHEMBL31619650 | 0.76 | KDM4E (0.59) | KDM4EALDH1A1MAPTGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255497-B1 | DAIDZIN DERIVATIVES AS ENZYME INHIBITORS OF ALDEHYDE DEHYDROGENASE; USEFUL IN TREATING ALCOHOLISM | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. | 2001-07-03 | — | — | US | disclosed |
| EP-0592583-A1 | METHOD FOR THE INHIBITION OF ALDH-I USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) | 1994-04-20 | — | — | EP | disclosed |
| WO-1993000896-A1 | METHOD FOR THE INHIBITION OF ALDH-I USEFUL IN THE TREATMENT OF ALCOHOL DEPENDENCE OR ALCOHOL ABUSE | THE ENDOWMENT FOR RESEARCH IN HUMAN BIOLOGY, INC. (US) | 1993-01-21 | — | — | WO | disclosed |