Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 11/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 11/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 11/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369039 | 0.86 | GABRA5 (0.53) | GABRA5GABRA3GABRA2GABRA1GABRB2 | |
| SCHEMBL3415178 | 0.81 | GABRG2 (0.77) | GABRA5GABRA3GABRA2GABRA1GABRB2 | |
| SCHEMBL7380104 | 0.80 | GABRA3 (0.58) | GABRA5GABRA3GABRA2GABRA1GABRB2 | |
| SCHEMBL7312677 | 0.79 | GABRA5 (0.57) | GABRA5GABRA3GABRA2GABRA1GABRB2 | |
| SCHEMBL11731330 | 0.74 | GABRA3 (0.64) | GABRA5GABRA3GABRA2GABRA1GABRB2 | |
| SCHEMBL7431448 | 0.73 | GABRA3 (0.66) | GABRA5GABRA3GABRA2GABRA1GABRB2 | |
| SCHEMBL11709742 | 0.72 | GABRA3 (0.66) | GABRA5GABRA3GABRA2GABRA1GABRB2 | |
| SCHEMBL19368522 | 0.72 | GABRG2 (0.58) | GABRA5GABRA3GABRA2GABRA1GABRG2 | |
| SCHEMBL3142139 | 0.72 | GABRG2 (0.58) | GABRA5GABRA3GABRA2GABRA1GABRG2 | |
| SCHEMBL7722605 | 0.72 | GABRG2 (0.58) | GABRA5GABRA3GABRA2GABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174881-B1 | USED AS ANXIOLYTIC AND/OR ANTICONVULSANT AND/OR MUSCLE RELAXANT AGENTS; SEDATIVES OR HYPNOSIS; WATER-SOLUBLE AMINE SALTS; FAST-ACTING | HOFFMAN-LA ROCHE INC. | 2001-01-16 | — | — | US | disclosed |