Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 11/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 10/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.53 |
| ▸ | GABRG2 | P18507 | 11/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 11/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7943655 | 0.86 | GABRA5 (0.55) | GABRA5GABRA3GABRA1GABRA2GABRB2 | |
| SCHEMBL7380104 | 0.79 | GABRA3 (0.58) | GABRA5GABRA3GABRA1GABRA2GABRB2 | |
| SCHEMBL3415178 | 0.77 | GABRG2 (0.77) | GABRA5GABRA3GABRA1GABRA2GABRB2 | |
| SCHEMBL7312677 | 0.74 | GABRA5 (0.57) | GABRA5GABRA3GABRA1GABRA2GABRB2 | |
| SCHEMBL11731330 | 0.72 | GABRA3 (0.64) | GABRA5GABRA3GABRA1GABRA2GABRB2 | |
| SCHEMBL7431448 | 0.71 | GABRA3 (0.66) | GABRA5GABRA3GABRA1GABRA2GABRB2 | |
| SCHEMBL11709742 | 0.71 | GABRA3 (0.66) | GABRA5GABRA3GABRA1GABRA2GABRB2 | |
| SCHEMBL3415181 | 0.70 | GABRA3 (0.56) | GABRA5GABRA3GABRA1GABRA2GABRB2 | |
| SCHEMBL11624016 | 0.70 | GABRA1 (1.00) | GABRA5GABRA3GABRA1GABRA2GABRB2 | |
| SCHEMBL11828965 | 0.70 | GABRA3 (0.73) | GABRA5GABRA3GABRA1GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801651-B1 | HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | disclosed |
| EP-0801651-A1 | HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-22 | — | — | EP | disclosed |
| WO-1996020941-A1 | HYDROXYMETHYLIMIDAZODIAZEPINES AND THEIR ESTERS | F. HOFFMANN-LA ROCHE AG (CH) | 1996-07-11 | — | — | WO | disclosed |