Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 14/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12446237 | 0.87 | BACE1 (0.47) | BACE1GRM4BACE2PRKCI | |
| SCHEMBL12445675 | 0.87 | BACE1 (0.49) | BACE1GRM4BACE2 | |
| SCHEMBL12445871 | 0.85 | BACE1 (0.47) | BACE1GRM4BACE2 | |
| SCHEMBL7941942 | 0.78 | SORT1 (0.41) | BACE1GRM4PRKCI | |
| SCHEMBL12445846 | 0.76 | GRM4 (0.38) | BACE1GRM4PRKCI | |
| SCHEMBL7941641 | 0.76 | BACE1 (0.62) | BACE1GRM4CYP2D6BACE2PRKCI | |
| SCHEMBL12445874 | 0.76 | ALDH1A1 (0.37) | BACE1GRM4PRKCI | |
| SCHEMBL12446239 | 0.73 | PRKCI (0.40) | BACE1BACE2PRKCI | |
| SCHEMBL12445770 | 0.71 | BACE1 (0.51) | BACE1BACE2 | |
| SCHEMBL12446184 | 0.71 | BACE1 (0.53) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |