Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 3/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7940603 | 0.90 | CD274 (0.35) | CD274PDE5APDCD1KDM5AKDM4C | |
| SCHEMBL7939410 | 0.83 | ALDH1A1 (0.38) | POLBMAPTHTTALDH1A1KMT2A | |
| SCHEMBL7940148 | 0.81 | CD274 (0.35) | NEK2CD274PTGDR2 | |
| SCHEMBL3233780 | 0.81 | GUCY1B2 (0.46) | — | |
| SCHEMBL3994180 | 0.80 | GUCY1B2 (0.45) | — | |
| SCHEMBL7940050 | 0.75 | KDM5A (0.35) | CD274PDCD1KDM5AKDM4CKDM5B | |
| SCHEMBL7941017 | 0.75 | MAPK1 (0.47) | POLBMAPTALDH1A1KMT2A | |
| SCHEMBL3228968 | 0.74 | GUCY1B2 (0.39) | PTGDR2 | |
| SCHEMBL3236702 | 0.74 | GUCY1B2 (0.43) | DGAT1 | |
| SCHEMBL3997847 | 0.73 | CETP (0.42) | DGAT1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |