Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GUCY1B2 | O75343 | 2/20 | 0.31 |
| ▸ | GUCY1A2 | P33402 | 2/20 | 0.31 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.31 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NEK2 | P51955 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7940603 | 0.81 | CD274 (0.35) | CD274NOTUM | |
| SCHEMBL7941017 | 0.81 | MAPK1 (0.47) | KDM4EHSD17B10TSHRHPGDTP53 | |
| SCHEMBL7944082 | 0.81 | NEK2 (0.36) | CD274PTGDR2NEK2 | |
| SCHEMBL7934714 | 0.77 | MAPT (0.36) | SMN1; SMN2 | |
| SCHEMBL3230736 | 0.77 | GUCY1B2 (0.50) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL7939410 | 0.75 | ALDH1A1 (0.38) | KDM4EHSD17B10GAATSHRCASP1 | |
| SCHEMBL7944340 | 0.73 | MAPT (0.36) | KDM4ETP53SMN1; SMN2CCR5 | |
| SCHEMBL19110961 | 0.68 | GUCY1B2 (0.54) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL7940050 | 0.66 | KDM5A (0.35) | CD274 | |
| SCHEMBL3229753 | 0.63 | GUCY1B2 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |