Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8014304 | 0.82 | HTR2A (0.36) | DRD2DRD4DRD3SMN1; SMN2 | |
| SCHEMBL7944942 | 0.80 | RET (0.35) | LTA4HDRD2DRD4DRD3SMN1; SMN2 | |
| SCHEMBL8020563 | 0.76 | HTR1A (0.35) | SMN1; SMN2 | |
| SCHEMBL7935372 | 0.75 | IDO1 (0.36) | — | |
| SCHEMBL8013011 | 0.74 | CHRM2 (0.31) | DRD2DRD4DRD3SMN1; SMN2 | |
| SCHEMBL10403793 | 0.70 | HTR2A (0.30) | — | |
| SCHEMBL7945043 | 0.69 | AADAT (0.40) | — | |
| SCHEMBL1025 | 0.62 | KCNA3 (0.88) | KCNA3LTA4HRECQLDRD2DRD4 | |
| SCHEMBL1490164 | 0.58 | KCNA3 (1.00) | KCNA3LTA4HRECQLDRD2DRD4 | |
| SCHEMBL1715718 | 0.57 | KCNA3 (0.68) | KCNA3LTA4HRECQLDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248750-B1 | CHOLINERGIC FUNCTION AGONISTS FOR MEMORY ENHANCEMENT | HOECHST ROUSSEL PHARMACEUTICALS | 2001-06-19 | — | — | US | disclosed |
| US-6075144-A | ABILITY TO INHIBIT ACETYLCHOLINESTERASE; TREATS ALZHEIMER,S DISEASE | HOECHST MARION ROUSSEL, INC. (US) | 2000-06-13 | — | — | US | disclosed |
| EP-0288852-B1 | 9-HYDROXYAMINO TETRAHYDRO-ACRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-28 | — | — | EP | disclosed |
| EP-0288852-A1 | 9-Hydroxyamino tetrahydro-acridines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-11-02 | — | — | EP | disclosed |