Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.53 |
| ▸ | SRC | P12931 | 3/20 | 0.44 |
| ▸ | XDH | P47989 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7946228 | 0.88 | MTOR (0.48) | MTOR | |
| SCHEMBL7947069 | 0.85 | MTOR (0.48) | MTORSRCXDHABL1EGFR | |
| SCHEMBL7947571 | 0.82 | PDE4B (0.47) | MTORSRCPDE4BABL1ADORA3 | |
| SCHEMBL7947917 | 0.80 | PDE4B (0.51) | MTORSRCPDE4BABL1ADORA3 | |
| SCHEMBL7938164 | 0.78 | PDE4B (0.42) | MTORSRCPDE4BABL1MAPK14 | |
| SCHEMBL7946067 | 0.78 | PDE4B (0.57) | PDE4BPDE4DTLR8KMT2AMAPK14 | |
| SCHEMBL7945984 | 0.78 | CYP1A2 (0.51) | PDE4BKMT2A | |
| SCHEMBL7947972 | 0.72 | CYP1A2 (0.57) | PDE4BKMT2A | |
| SCHEMBL7944713 | 0.70 | CYP1A2 (0.47) | PDE4BKMT2A | |
| SCHEMBL7938047 | 0.70 | CYP1A2 (0.56) | MTORSRCABL1EGFRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008775-A1 | AMINOPYRIDOPYRAZINONE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | disclosed |