Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | RORA | P35398 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | RORB | Q92753 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947917 | 0.94 | PDE4B (0.51) | PDE4BTLR8MEN1KMT2AMAPK14 | |
| SCHEMBL7947571 | 0.89 | PDE4B (0.47) | PDE4BTLR8MAPK14ADORA2AADORA2B | |
| SCHEMBL7945984 | 0.87 | CYP1A2 (0.51) | PDE4BMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL7945959 | 0.86 | PDE4B (0.51) | PDE4BTP53MEN1KMT2AALDH1A1 | |
| SCHEMBL7938164 | 0.83 | PDE4B (0.42) | PDE4BMAPK14CLK4 | |
| SCHEMBL7938416 | 0.82 | CYP1A2 (0.50) | PDE4BTLR8MEN1KMT2AALDH1A1 | |
| SCHEMBL7946753 | 0.80 | ALDH1A1 (0.52) | TP53MEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL7944647 | 0.78 | MTOR (0.53) | PDE4BTLR8PDE4DKMT2AMAPK14 | |
| SCHEMBL7944713 | 0.78 | CYP1A2 (0.47) | PDE4BMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL7944114 | 0.77 | PDE4B (0.48) | PDE4BTLR8PDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008775-A1 | AMINOPYRIDOPYRAZINONE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | disclosed |