SCHEMBL7944766

SCHEMBL7944766

O=C(OCCCl)c1ccccc1CCl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.50
TSHR P16473 8/20 0.49
TDP1 Q9NUW8 5/20 0.47
L3MBTL1 Q9Y468 4/20 0.47
CYP3A4 P08684 3/20 0.46
MAPK1 P28482 3/20 0.46
TP53 P04637 2/20 0.46
LMNA P02545 1/20 0.45
SCN1A P35498 2/20 0.43
SCN2A Q99250 2/20 0.43
SCN3A Q9NY46 2/20 0.43
CASP3 P42574 1/20 0.43
SENP8 Q96LD8 1/20 0.43
SENP7 Q9BQF6 1/20 0.43
SENP6 Q9GZR1 1/20 0.43
HSD17B10 Q99714 2/20 0.41
NPC1 O15118 2/20 0.41
GLA P06280 1/20 0.41
HPGD P15428 1/20 0.41
RAB9A P51151 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27933890 0.88 ALDH1A1 (0.58) ALDH1A1TSHRTDP1L3MBTL1CYP3A4
SCHEMBL6517486 0.87 ALDH1A1 (0.64) ALDH1A1TSHRTDP1L3MBTL1CYP3A4
SCHEMBL27685154 0.86 ALDH1A1 (0.47) ALDH1A1TSHRTDP1L3MBTL1CYP3A4
SCHEMBL6596574 0.86 ALDH1A1 (0.71) ALDH1A1TSHRTDP1L3MBTL1CYP3A4
SCHEMBL7211498 0.85 TSHR (0.47) ALDH1A1TSHRTDP1L3MBTL1CYP3A4
SCHEMBL5679381 0.83 TSHR (0.73) ALDH1A1TSHRTDP1L3MBTL1CYP3A4
SCHEMBL8459868 0.82 TSHR (0.73) ALDH1A1TSHRTDP1L3MBTL1CYP3A4
SCHEMBL7946320 0.82 ALDH1A1 (0.44) ALDH1A1TSHRTDP1L3MBTL1CYP3A4
SCHEMBL2825239 0.82 TSHR (0.69) ALDH1A1TSHRTDP1L3MBTL1CYP3A4
SCHEMBL8731468 0.81 ALDH1A1 (0.43) ALDH1A1TSHRTDP1L3MBTL1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6222060-B1 REACTING LACTONE COMPOUND WITH THIONYL CHLORIDE; ESTERIFYING WITH ALCOHOL; REACTING WITH SALT OF THIOSULFONIC ACID; CHLORINATING TO PREPARE O-(CARBOALKOXY)PHENYLMETHANESULFONYL CHLORIDE DERIVATIVE KOREAN RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2001-04-24 US disclosed
WO-1999016743-A1 A PROCESS FOR PREPARING o-(CARBOALKOXY) PHENYLMETHANESULFONYL CHLORIDE DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1999-04-08 WO disclosed