SCHEMBL7945165

SCHEMBL7945165

COc1ccc(C(C)C)c2c1-c1ccccc1[CH]2

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.46
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
ALDH1A1 P00352 3/20 0.46
USP2 O75604 2/20 0.46
KDM4E B2RXH2 1/20 0.46
DUSP3 P51452 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
CA1 P00915 4/20 0.44
CA2 P00918 4/20 0.44
CA7 P43166 4/20 0.44
CA9 Q16790 4/20 0.44
RAB9A P51151 3/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
MAPK1 P28482 2/20 0.43
POLB P06746 2/20 0.43
FGB P02675 1/20 0.43
THRB P10828 1/20 0.43
ADORA2A P29274 1/20 0.43
PPARG P37231 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1028895 0.83 CA1 (0.34) CA1CA2CA7CA9LMNA
SCHEMBL9412850 0.74 SMN1; SMN2 (0.35) MAPTMEN1KMT2AALDH1A1USP2
SCHEMBL7525316 0.71 CA1 (0.47) MAPTMEN1KMT2AALDH1A1USP2
SCHEMBL617021 0.71 GABRA1 (0.40) KMT2ACA1CA2CA9LMNA
SCHEMBL4723230 0.70 ALDH1A1 (0.43) MAPTMEN1KMT2AALDH1A1USP2
SCHEMBL13888684 0.69 MEN1 (0.50) MAPTMEN1KMT2AALDH1A1USP2
SCHEMBL4721475 0.69 MAPT (0.50) MAPTMEN1KMT2AALDH1A1USP2
SCHEMBL218360 0.67 CA1 (0.46) MAPTMEN1KMT2AALDH1A1USP2
SCHEMBL218366 0.67 RAB9A (0.47) MAPTMEN1KMT2AALDH1A1USP2
SCHEMBL2688204 0.67 CDC25A (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0773239-A2 Method for controlling the melting points and molecular weights of syndiotactic polyolefins using metallocene catalyst systems FINA TECHNOLOGY, INC. (US) 1997-05-14 EP claimed
EP-0773238-A2 Method for controlling the melting points and molecular weights of syndiotactic polyolefins using metallocene catalyst systems FINA TECHNOLOGY, INC. (US) 1997-05-14 EP claimed
EP-0577581-A2 Method for controlling the melting points and molecular weights of syndiotactic polyolefins using metallocene catalyst systems FINA TECHNOLOGY, INC. (US) 1994-01-05 EP claimed
EP-0773239-B1 Method for controlling the melting points and molecular weights of syndiotactic polyolefins using metallocene catalyst systems FINA TECHNOLOGY (US) 2001-12-05 EP disclosed