Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 5/20 | 0.41 |
| ▸ | SI | P14410 | 5/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 5/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | FASN | P49327 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8024217 | 0.87 | PDCD1 (0.56) | PDCD1CD274ERN1CYP11B1CYP11B2 | |
| SCHEMBL7941955 | 0.82 | AKR1C3 (0.45) | PDCD1CD274MGAMGAASI | |
| SCHEMBL7944717 | 0.79 | CYP11B1 (0.45) | PDCD1CD274CYP11B1CYP11B2GCGR | |
| SCHEMBL7941958 | 0.74 | PTGDR2 (0.39) | PDCD1CD274GCGRPPARDMAPT | |
| SCHEMBL2017497 | 0.73 | CNR2 (0.53) | ALDH1A1MEN1KMT2A | |
| SCHEMBL15777952 | 0.72 | MAPT (0.48) | KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL3414121 | 0.72 | KDM4E (0.44) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL8012943 | 0.72 | PDCD1 (0.43) | PDCD1CD274ERN1CYP11B1CYP11B2 | |
| SCHEMBL8017441 | 0.72 | PDCD1 (0.61) | PDCD1CD274CYP11B1CYP11B2KDM4E | |
| SCHEMBL5753110 | 0.72 | ALDH1A1 (0.54) | CYP11B1CYP11B2KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |