Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 4/20 | 0.61 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.61 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.44 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.44 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.44 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.44 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.44 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.44 |
| ▸ | CYP2F1 | P24903 | 1/20 | 0.44 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7946481 | 0.88 | CYP11B1 (0.48) | PDCD1CD274CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL8024217 | 0.84 | PDCD1 (0.56) | PDCD1CD274CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL7946478 | 0.82 | CYP1A1 (0.55) | PDCD1CD274CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL8028294 | 0.81 | PDCD1 (0.58) | PDCD1CD274APLNRPDE5APDE4A | |
| SCHEMBL4050630 | 0.81 | PDCD1 (0.52) | PDCD1CD274CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL238087 | 0.81 | APLNR (0.63) | PDCD1CD274CYP1A2CYP1A1CYP3A4 | |
| SCHEMBL8016866 | 0.80 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL30830335 | 0.80 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL679848 | 0.79 | SMN1; SMN2 (0.55) | CYP11B1CYP11B2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL3127408 | 0.77 | ALDH1A1 (0.47) | CYP11B1CYP11B2APLNRPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |