Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3990742 | 0.87 | KMT2A (0.34) | KMT2AHPGDPOLBTSHRSMN1; SMN2 | |
| SCHEMBL3988351 | 0.83 | TSHR (0.36) | TSHRSMN1; SMN2 | |
| SCHEMBL3994095 | 0.81 | L3MBTL1 (0.39) | KMT2ASLC6A4HPGDPOLBRXRA | |
| SCHEMBL3992362 | 0.81 | KMT2A (0.37) | KMT2ASLC6A4HPGDPOLBRXRA | |
| SCHEMBL1711665 | 0.79 | MEN1 (0.53) | MRGPRX1KMT2AHTR1ASLC6A2SLC6A3 | |
| SCHEMBL19994256 | 0.77 | KDM4E (0.51) | MRGPRX1KMT2AHTR1ASLC6A2SLC6A4 | |
| SCHEMBL2897755 | 0.76 | SMN1; SMN2 (0.55) | MRGPRX1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL693585 | 0.76 | KMT2A (0.49) | KMT2AHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL919536 | 0.75 | LTA4H (0.48) | MRGPRX1HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2753021 | 0.73 | TRPA1 (0.40) | KMT2AHTR1ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235758-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-22 | — | — | US | disclosed |
| EP-0808312-B1 | INDOLE DERIVATIVES AS 5-HT RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM PLC (GB) | 2000-11-02 | — | — | EP | disclosed |
| US-5990133-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS ANXIETY OR DEPRESSION | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |