Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 6/20 | 0.41 |
| ▸ | KIF11 | P52732 | 4/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | AGXT | P21549 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7935451 | 0.86 | PPARD (0.43) | PPARDKIF11TRPV1MCHR1ALOX5 | |
| SCHEMBL7944912 | 0.78 | TSHR (0.39) | — | |
| SCHEMBL7936111 | 0.77 | ERN1 (0.46) | PPARDKIF11MCHR1ALOX5PSEN1 | |
| SCHEMBL4602156 | 0.76 | PTPN11 (0.60) | PPARDALOX5PSEN1PPARA | |
| SCHEMBL3230214 | 0.74 | RXRA (0.50) | KIF11PSEN1AGXT | |
| SCHEMBL2056314 | 0.74 | CYP1A1 (0.56) | PPARDKIF11PPARACYP1A1CYP1B1 | |
| SCHEMBL3235607 | 0.72 | HPGD (0.50) | — | |
| SCHEMBL14610858 | 0.72 | PTPN11 (0.46) | PPARDKIF11MCHR1ALOX5PSEN1 | |
| SCHEMBL12650491 | 0.72 | KIF11 (0.55) | PPARDKIF11MCHR1PPARGPPARA | |
| SCHEMBL13756268 | 0.71 | KIF11 (0.40) | PPARDKIF11MCHR1ALOX5PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015653-A1 | PYRIMIDINE DERIVATIVES AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |