Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 10/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | CHUK | O15111 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2157288 | 0.85 | MKNK1 (0.46) | CYP2C9GAACYP11B2 | |
| SCHEMBL7953665 | 0.81 | MKNK1 (0.47) | KMT2ACYP11B2 | |
| SCHEMBL2158167 | 0.80 | SIRT3 (0.46) | CDC7CDK9MEN1CYP1A2CYP3A4 | |
| SCHEMBL7955655 | 0.75 | WNT1 (0.35) | CDC7CDK9MEN1KMT2AGAA | |
| SCHEMBL7960316 | 0.75 | KDM4A (0.35) | CDC7CDK9MEN1KMT2AGAA | |
| SCHEMBL7946519 | 0.75 | PLAU (0.41) | CYP3A4GAA | |
| SCHEMBL7957597 | 0.75 | HPGD (0.37) | GAAIKBKB | |
| SCHEMBL7954859 | 0.75 | MKNK1 (0.43) | GAA | |
| SCHEMBL7953705 | 0.73 | CYP2C9 (0.43) | MEN1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7953580 | 0.72 | CYP11B1 (0.37) | MEN1CYP2C19KMT2ACYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |
| EP-0833635-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | Aventis Pharma S.A. (FR) | 1998-04-08 | — | — | EP | disclosed |
| WO-1997000073-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | RHONE-POULENC RORER S.A. (FR) | 1997-01-03 | — | — | WO | disclosed |