Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2157932 | 0.84 | ALDH1A1 (0.40) | CYP11B1CYP11B2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7954901 | 0.80 | CYP11B2 (0.40) | CYP11B1CYP11B2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2157447 | 0.79 | CYP11B2 (0.43) | CYP11B1CYP11B2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7588929 | 0.79 | CYP11B1 (0.42) | CYP11B1CYP11B2ALDH1A1HPGDLMNA | |
| SCHEMBL12988242 | 0.75 | MAOA (0.46) | CYP11B1CYP11B2ALDH1A1HPGDKDM4E | |
| SCHEMBL7592203 | 0.74 | CNR2 (0.37) | CYP11B1CYP11B2ALDH1A1KDM4EABCC1 | |
| SCHEMBL7590022 | 0.74 | CYP11B2 (0.38) | CYP11B1CYP11B2ALDH1A1HPGDABCC1 | |
| SCHEMBL7953649 | 0.74 | CYP11B2 (0.44) | CYP11B1CYP11B2ALDH1A1ABCC1ABCG2 | |
| SCHEMBL7946362 | 0.72 | CDC7 (0.50) | CYP11B2MEN1KMT2ACYP2C19 | |
| SCHEMBL7953706 | 0.70 | ABCC1 (0.43) | ALDH1A1HPGDKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |
| EP-0833635-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | Aventis Pharma S.A. (FR) | 1998-04-08 | — | — | EP | disclosed |
| WO-1997000073-A1 | NOVEL USE FOR PYRROLE DERIVATIVES | RHONE-POULENC RORER S.A. (FR) | 1997-01-03 | — | — | WO | disclosed |