Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7946519 | 0.86 | PLAU (0.41) | MAPTGAASYKKCNK3LMNA | |
| SCHEMBL7954859 | 0.86 | MKNK1 (0.43) | HPGDSMN1; SMN2MAPTRAB9AGAA | |
| SCHEMBL8329574 | 0.81 | PTPN11 (0.33) | SMN1; SMN2MAPTRAB9AALDH1A1LMNA | |
| SCHEMBL7955658 | 0.79 | MEN1 (0.35) | HPGDSMN1; SMN2MAPTRAB9AGAA | |
| SCHEMBL7955530 | 0.77 | HPGD (0.39) | HPGDSMN1; SMN2MAPTRAB9AGAA | |
| SCHEMBL7946450 | 0.77 | RAB9A (0.36) | HPGDSMN1; SMN2MAPTRAB9AGAA | |
| SCHEMBL2157288 | 0.76 | MKNK1 (0.46) | GAA | |
| SCHEMBL7592203 | 0.76 | CNR2 (0.37) | GAAALDH1A1KDM4E | |
| SCHEMBL7946362 | 0.75 | CDC7 (0.50) | GAAIKBKB | |
| SCHEMBL7946357 | 0.75 | HPGD (0.38) | HPGDSMN1; SMN2MAPTRAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |