Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 6/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955650 | 0.96 | ABCC1 (0.42) | ALDH1A1KDM4EHSD17B10ABCC1ABCG2 | |
| SCHEMBL7954831 | 0.86 | ALDH1A1 (0.39) | ALDH1A1KDM4EHSD17B10ABCC1ABCG2 | |
| SCHEMBL7946444 | 0.83 | ALDH1A1 (0.43) | ALDH1A1KDM4EHSD17B10ABCC1ABCG2 | |
| SCHEMBL7946457 | 0.82 | ALDH1A1 (0.42) | ALDH1A1KDM4EHSD17B10ABCC1ABCG2 | |
| SCHEMBL7960169 | 0.82 | ABCC1 (0.42) | ALDH1A1KDM4EHSD17B10ABCC1ABCG2 | |
| SCHEMBL7955644 | 0.80 | CYP11B2 (0.35) | KDM4ECYP11B2PDE2APDE10A | |
| SCHEMBL7953127 | 0.79 | KCNMA1 (0.36) | PTGS2CYP11B2PDE2APDE10A | |
| SCHEMBL7961423 | 0.77 | CYP11B2 (0.37) | KDM4ECYP11B2PDE2APDE10A | |
| SCHEMBL7954939 | 0.74 | PLAU (0.38) | ALDH1A1KDM4EABCC1HTT | |
| SCHEMBL7590017 | 0.73 | CYP11B2 (0.44) | ALDH1A1KDM4EHSD17B10ABCC1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |