Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.30 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.30 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7946431 | 0.80 | ALDH1A1 (0.39) | CYP11B2PDE2APDE10AKDM4E | |
| SCHEMBL7955650 | 0.79 | ABCC1 (0.42) | CYP11B2KDM4EGFER | |
| SCHEMBL7961423 | 0.74 | CYP11B2 (0.37) | CYP11B2PDE2APDE10ACYP11B1KDM4E | |
| SCHEMBL7953127 | 0.71 | KCNMA1 (0.36) | CYP11B2PDE2APDE10ADHODH | |
| SCHEMBL7946510 | 0.66 | CYP11B2 (0.42) | CYP11B2CYP11B1KDM4EKMT2A | |
| SCHEMBL7946444 | 0.66 | ALDH1A1 (0.43) | CYP11B2KDM4EGFER | |
| SCHEMBL7954831 | 0.66 | ALDH1A1 (0.39) | KDM4EMEN1KMT2A | |
| SCHEMBL7960169 | 0.65 | ABCC1 (0.42) | KDM4EMEN1GFERKMT2A | |
| SCHEMBL7946457 | 0.65 | ALDH1A1 (0.42) | CYP11B2KDM4EMEN1GFERKMT2A | |
| SCHEMBL7967472 | 0.64 | CYP11B2 (0.39) | CYP11B2PDE2APDE10ACYP11B1CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |