Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955633 | 0.90 | CYP2C19 (0.59) | CYP2C19POLBALDH1A1SMN1; SMN2P2RX7 | |
| SCHEMBL7953661 | 0.87 | CYP2C19 (0.45) | CYP2C19POLBALDH1A1NR1D1KDM4E | |
| SCHEMBL7953694 | 0.84 | SMN1; SMN2 (0.48) | CYP2C19POLBALDH1A1SMN1; SMN2CDC25B | |
| SCHEMBL7954837 | 0.84 | CYP2C19 (0.65) | CYP2C19POLBALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL10860840 | 0.78 | GAA (0.59) | ALDH1A1KDM4EL3MBTL1GAANPC1 | |
| SCHEMBL7955525 | 0.77 | SMN1; SMN2 (0.48) | CYP2C19POLBALDH1A1SMN1; SMN2CDC25B | |
| SCHEMBL7954849 | 0.73 | POLB (0.51) | CYP2C19POLBALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7589095 | 0.72 | ALDH1A1 (0.52) | CYP2C19POLBALDH1A1SMN1; SMN2NR1D1 | |
| SCHEMBL7363975 | 0.71 | CYP2C19 (0.52) | CYP2C19POLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7946411 | 0.71 | CYP2C19 (0.48) | CYP2C19POLBALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |