Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7946469 | 0.90 | CYP2C19 (0.61) | CYP2C19POLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7955525 | 0.83 | SMN1; SMN2 (0.48) | CYP2C19POLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7954837 | 0.80 | CYP2C19 (0.65) | CYP2C19POLBSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL7953661 | 0.77 | CYP2C19 (0.45) | CYP2C19POLBALDH1A1NPSR1NR1D1 | |
| SCHEMBL7953694 | 0.76 | SMN1; SMN2 (0.48) | CYP2C19POLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL9724034 | 0.72 | KMT2A (0.50) | POLBSMN1; SMN2ALDH1A1HSD17B10NR1D1 | |
| SCHEMBL20366905 | 0.70 | NR1D1 (0.46) | CYP2C19ALDH1A1NPSR1HSD17B10NR1D1 | |
| SCHEMBL49913 | 0.70 | POLB (0.66) | CYP2C19POLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL13469115 | 0.70 | MEN1 (0.45) | POLBSMN1; SMN2ALDH1A1NPSR1HSD17B10 | |
| SCHEMBL7051453 | 0.69 | ALDH1A1 (0.41) | POLBSMN1; SMN2ALDH1A1NPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |