Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7954849 | 0.89 | POLB (0.51) | CYP2C19MEN1KMT2APOLBTSHR | |
| SCHEMBL7589095 | 0.88 | ALDH1A1 (0.52) | CYP2C19MEN1KMT2APOLBTSHR | |
| SCHEMBL7946411 | 0.87 | CYP2C19 (0.48) | CYP2C19MEN1KMT2APOLBTSHR | |
| SCHEMBL7946469 | 0.84 | CYP2C19 (0.61) | CYP2C19POLBALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL13468059 | 0.83 | TP53 (0.55) | MEN1KMT2ATSHRALDH1A1FKBP1A | |
| SCHEMBL7957115 | 0.83 | SMN1; SMN2 (0.48) | CYP2C19POLBTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL13469108 | 0.81 | KDM4E (0.54) | MEN1KMT2APOLBTSHRALDH1A1 | |
| SCHEMBL7955633 | 0.80 | CYP2C19 (0.59) | CYP2C19POLBALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL7363975 | 0.80 | CYP2C19 (0.52) | CYP2C19POLBALDH1A1FKBP1ASMN1; SMN2 | |
| SCHEMBL20366865 | 0.79 | ALDH1A1 (0.56) | MEN1KMT2ATSHRALDH1A1FKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |