Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | REN | P00797 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | FCER2 | P06734 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7839117 | 1.00 | KMT2A (0.41) | KMT2AMMEACECPA1ACE2 | |
| SCHEMBL7946604 | 0.85 | CTSS (0.47) | MMEACECPA1ACE2MAPT | |
| SCHEMBL7840436 | 0.85 | CTSS (0.47) | MMEACECPA1ACE2MAPT | |
| SCHEMBL7836648 | 0.76 | MAPT (0.40) | KMT2AMAPTNPSR1POLBREN | |
| SCHEMBL7955112 | 0.76 | MAPT (0.40) | KMT2AMAPTNPSR1POLBREN | |
| SCHEMBL7827850 | 0.76 | MMP1 (0.46) | KMT2AMAPTNPSR1POLBREN | |
| SCHEMBL7836454 | 0.76 | MMP1 (0.46) | KMT2AMAPTNPSR1POLBREN | |
| SCHEMBL7853162 | 0.76 | MMP1 (0.46) | KMT2AMAPTNPSR1POLBREN | |
| SCHEMBL7853167 | 0.76 | MMP1 (0.46) | KMT2AMAPTNPSR1POLBREN | |
| SCHEMBL8107306 | 0.76 | ADAM17 (0.35) | KMT2AMAPTNPSR1POLBREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |