Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 6/20 | 0.44 |
| ▸ | ACACA | Q13085 | 4/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13459733 | 0.82 | GLS (0.44) | GLSNPC1RAB9ABRD4CREBBP | |
| SCHEMBL185365 | 0.81 | ATM (0.55) | GLSBRD4CA12CA1CA7 | |
| SCHEMBL3125633 | 0.81 | NPC1 (0.57) | NPC1RAB9AHDAC6CYP1A2CYP2C9 | |
| SCHEMBL25048390 | 0.81 | BRD4 (0.47) | GLSBRD4CREBBPROCK2 | |
| SCHEMBL3244499 | 0.79 | GLS (0.46) | GLSBRD4CREBBPROCK2CA12 | |
| SCHEMBL30779221 | 0.79 | ROCK2 (0.54) | GLSBRD4CREBBPROCK2CYP3A4 | |
| SCHEMBL24732888 | 0.79 | ROCK2 (0.54) | GLSBRD4CREBBPROCK2CYP3A4 | |
| SCHEMBL694491 | 0.78 | GLS (0.56) | GLSBRD4CREBBPCYP3A4CA12 | |
| SCHEMBL30531063 | 0.78 | GLS (0.48) | GLSBRD4CREBBPROCK2 | |
| SCHEMBL25358558 | 0.78 | GLS (0.48) | GLSBRD4CREBBPROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |