Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 5/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGAV | P06756 | 1/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457367 | 0.91 | ITGB3 (0.50) | ROCK2ITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL7947169 | 0.89 | EPHX2 (0.43) | GLSROCK2BRD4CREBBPITGB3 | |
| SCHEMBL7946795 | 0.79 | GLS (0.48) | GLSROCK2BRD4CREBBPCA12 | |
| SCHEMBL8202738 | 0.79 | CACNA1B (0.48) | ROCK2ITGB3ITGB1ITGAVITGA5 | |
| SCHEMBL29228688 | 0.77 | ITGB3 (0.55) | ITGB3ITGB1ITGAVITGA5KMT2A | |
| SCHEMBL1410181 | 0.77 | ITGB3 (0.55) | ITGB3ITGB1ITGAVITGA5KMT2A | |
| SCHEMBL24732888 | 0.77 | ROCK2 (0.54) | GLSROCK2BRD4CREBBPKMT2A | |
| SCHEMBL30779221 | 0.77 | ROCK2 (0.54) | GLSROCK2BRD4CREBBPKMT2A | |
| SCHEMBL25048390 | 0.76 | BRD4 (0.47) | GLSROCK2BRD4CREBBPKMT2A | |
| SCHEMBL17147653 | 0.76 | ITGB3 (0.53) | ITGB3ITGB1ITGAVITGA5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |