Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | NAMPT | P43490 | 1/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | TGM2 | P21980 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MMP2 | P08253 | 2/20 | 0.56 |
| ▸ | MMP9 | P14780 | 2/20 | 0.56 |
| ▸ | KDM1A | O60341 | 2/20 | 0.55 |
| ▸ | MAOA | P21397 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | MGLL | Q99685 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2329360 | 0.88 | MGLL (0.55) | POLBNAMPTROCK2TGM2TP53 | |
| SCHEMBL2329710 | 0.87 | MGLL (0.54) | POLBNAMPTROCK2TGM2TP53 | |
| SCHEMBL14183602 | 0.86 | CA2 (0.63) | POLBNAMPTTGM2TP53MAPT | |
| Benzyl Phenylcarbamate SCHEMBL1222943 | 0.83 | POLB (0.78) | POLBROCK2TP53MAPTKDM1A | |
| SCHEMBL14183716 | 0.82 | TGM2 (0.65) | POLBNAMPTTGM2TP53MAPT | |
| SCHEMBL3795024 | 0.82 | POLB (0.68) | POLBROCK2TP53MAPTKDM1A | |
| SCHEMBL1870929 | 0.82 | POLB (0.71) | POLBNAMPTROCK2TP53MAPT | |
| SCHEMBL4832606 | 0.81 | CYP2D6 (0.62) | POLBNAMPTTGM2TP53MAPT | |
| SCHEMBL12045682 | 0.81 | POLB (0.66) | POLBROCK2TP53MAPTKDM1A | |
| SCHEMBL10642358 | 0.81 | POLB (0.66) | POLBROCK2TP53MAPTKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6270957-B1 | USEFUL IN THE TREATMENT AND PREVENTION OF HIV (HUMAN IMMUNODEFICIENCY VIRUS)-MEDIATED DISORDERS, INCLUDING AIDS (ACQUIRE IMMUNODEFICIENCY SYNDROME) | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2001-08-07 | — | — | US | disclosed |
| WO-1999010373-A1 | NON-IMMUNOSUPPRESSIVE CYCLOSPORINS AND THEIR USE IN THE PREVENTION AND TREATMENT OF HIV INFECTION | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-03-04 | — | — | WO | disclosed |