Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 6/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | MMP1 | P03956 | 3/20 | 0.38 |
| ▸ | MMP9 | P14780 | 3/20 | 0.38 |
| ▸ | MMP13 | P45452 | 3/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.38 |
| ▸ | MME | P08473 | 5/20 | 0.36 |
| ▸ | ACE | P12821 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL648053 | 0.84 | LMNA (0.41) | MEN1LMNAKMT2AMMP1MMP9 | |
| SCHEMBL10284665 | 0.84 | LMNA (0.41) | MEN1LMNAKMT2AMMP1MMP9 | |
| SCHEMBL13140315 | 0.74 | XIAP (0.45) | XIAPCYP3A4MMEACECCKBR | |
| SCHEMBL10201707 | 0.74 | LMNA (0.41) | MEN1LMNAKMT2A | |
| SCHEMBL10249419 | 0.74 | LMNA (0.41) | MEN1LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL646346 | 0.73 | FAAH (0.47) | XIAPCYP3A4MMP1MMP9MMP13 | |
| SCHEMBL7347045 | 0.71 | ACE (0.56) | MEN1LMNAKMT2AXIAPMME | |
| SCHEMBL14599932 | 0.71 | MMP1 (0.39) | XIAPCYP3A4MMP1MMP9MMP13 | |
| SCHEMBL4070879 | 0.70 | GAA (0.40) | MEN1KMT2AXIAPCYP3A4ACE | |
| SCHEMBL4425590 | 0.70 | NOTUM (0.46) | LMNAXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258948-B1 | AN N-ACYLAMINO COMPOUND; ANTIINFLAMMATORY AGENTS, AUTOIMMUNE DISEASES | VERTEX PHARMACEUTICALS, INCORPORATED | 2001-07-10 | — | — | US | disclosed |