Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.60 |
| ▸ | LIPE | Q05469 | 8/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956252 | 1.00 | LIPG (0.60) | LIPGLIPEHSD11B1HRH3SCD | |
| SCHEMBL7956524 | 1.00 | LIPG (0.60) | LIPGLIPEHSD11B1HRH3SCD | |
| SCHEMBL7961541 | 0.93 | LIPG (0.53) | LIPGLIPEHSD11B1HRH3CYP3A4 | |
| SCHEMBL7961398 | 0.85 | LIPG (0.57) | LIPGLIPEHSD11B1HRH3SCD | |
| SCHEMBL29935534 | 0.85 | LIPG (0.59) | LIPGLIPEHSD11B1HRH3NOTUM | |
| SCHEMBL29935625 | 0.85 | LIPG (0.57) | LIPGLIPEHSD11B1HRH3SCN3A | |
| SCHEMBL7947575 | 0.85 | LIPG (0.57) | LIPGLIPEHSD11B1HRH3SCD | |
| Ammonia Solution, Strong SCHEMBL23703282 | 0.84 | LIPG (0.58) | LIPGLIPEHSD11B1HRH3NOTUM | |
| SCHEMBL7947501 | 0.84 | LIPG (0.61) | LIPGLIPEHSD11B1HRH3SCD | |
| SCHEMBL7958655 | 0.84 | LIPG (0.50) | LIPGSCDNOTUMCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |