Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947468 | 0.86 | CYP19A1 (0.49) | HTR1ASLC6A2SLC6A4SLC6A3HRH1 | |
| SCHEMBL7958198 | 0.84 | CCR5 (0.52) | HTR1ASLC6A2SLC6A4SLC6A3HRH1 | |
| SCHEMBL7947463 | 0.83 | HRH3 (0.61) | HRH1HRH3KDM4ESMN1; SMN2MAOB | |
| SCHEMBL7954927 | 0.82 | HRH1 (0.52) | HTR1ASLC6A2SLC6A4SLC6A3HRH1 | |
| Hydrochloric Acid SCHEMBL2384578 | 0.75 | HTR1A (0.77) | HTR1ASLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL7956560 | 0.75 | KDM4E (0.65) | HRH1HRH3KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL17827687 | 0.73 | HRH1 (0.53) | HTR1AHRH1HRH3KDM4EHTR6 | |
| SCHEMBL7958273 | 0.73 | HRH1 (0.58) | HRH1HRH3KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL7958206 | 0.73 | CCR5 (0.50) | HTR1ASLC6A2SLC6A4SLC6A3HRH1 | |
| SCHEMBL8634780 | 0.73 | SMN1; SMN2 (0.48) | HRH1HRH3KDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |