SCHEMBL8634780

SCHEMBL8634780

C=CCOc1ccccc1N1CCN(c2ccncc2)CC1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.48
METAP1 P53582 1/20 0.45
DRD2 P14416 1/20 0.42
DRD4 P21917 1/20 0.42
DRD3 P35462 1/20 0.42
SLC2A1 P11166 1/20 0.42
SLC2A2 P11168 1/20 0.42
SLC2A3 P11169 1/20 0.42
ALDH1A1 P00352 2/20 0.41
LMNA P02545 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
KDM4E B2RXH2 1/20 0.41
HRH1 P35367 2/20 0.41
HRH3 Q9Y5N1 2/20 0.41
SETDB1 Q15047 1/20 0.41
HRH2 P25021 1/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
HSD17B10 Q99714 1/20 0.40
CHKA P35790 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15881007 0.80 DRD2 (0.59) DRD2DRD4DRD3ALDH1A1KDM4E
SCHEMBL15880500 0.80 POLB (0.49) SMN1; SMN2DRD2DRD4DRD3ALDH1A1
SCHEMBL15881097 0.80 SETDB1 (0.52) DRD2DRD4DRD3ALDH1A1LMNA
SCHEMBL8634783 0.79 GAA (0.47) SMN1; SMN2METAP1DRD4HRH1HRH3
SCHEMBL7329611 0.79 METAP1 (0.52) METAP1HRH1HRH3HRH2CHKA
SCHEMBL11032101 0.77 HTR1A (0.62) DRD2DRD3LMNA
SCHEMBL8634183 0.77 DRD2 (0.63) SMN1; SMN2DRD2DRD3SLC2A1SLC2A2
SCHEMBL7398342 0.76 ITGB3 (0.49) SMN1; SMN2ALDH1A1LMNAL3MBTL1HRH1
SCHEMBL7399702 0.76 SMN1; SMN2 (0.54) SMN1; SMN2DRD2DRD4DRD3ALDH1A1
SCHEMBL7958198 0.75 CCR5 (0.52) SMN1; SMN2DRD2DRD4DRD3LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5753659-A ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, ZENECA LIMITED (GB) 1998-05-19 US disclosed
US-5750754-A TERTIARY BUTYL 3-METHYL-4-SUBSTITUTED BUTYRATE; CHEMICAL INTERMEDIATES FOR ANTICAOGULANT DRUGS ZENECA LIMITED (GB) 1998-05-12 US disclosed
US-5728701-A INHIBIT PLATELET AGGREGATION ZENECA LIMITED (GB) 1998-03-17 US disclosed