Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CYP46A1 | Q9Y6A2 | 3/20 | 0.33 |
| ▸ | IKBKB | O14920 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956455 | 0.85 | ROCK2 (0.37) | CA12CA1CA2CA9LIPG | |
| SCHEMBL7958631 | 0.79 | HRH3 (0.43) | CYP11B2HRH3 | |
| SCHEMBL11907738 | 0.79 | MAPT (0.40) | — | |
| SCHEMBL4555535 | 0.79 | MAPT (0.40) | — | |
| SCHEMBL4435998 | 0.79 | MAPT (0.40) | — | |
| SCHEMBL30784155 | 0.77 | PBRM1 (0.33) | GBA1 | |
| SCHEMBL30784128 | 0.77 | PBRM1 (0.33) | GBA1 | |
| SCHEMBL25232014 | 0.76 | CA1 (0.39) | CA12CA1CA2CA9LIPG | |
| SCHEMBL30466332 | 0.76 | CA1 (0.39) | CA12CA1CA2CA9LIPG | |
| SCHEMBL25277048 | 0.76 | CA1 (0.39) | CA12CA1CA2CA9LIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |