Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4932531 | 0.79 | LTB4R (0.51) | RECQLMCL1CDK1KDM4EALDH1A1 | |
| SCHEMBL27776002 | 0.75 | LTB4R (0.44) | MPOCDK1KDM4EALDH1A1GAA | |
| SCHEMBL11307118 | 0.72 | SLC29A1 (0.45) | MPOHTR2BGPR68ADORA2AKMT2A | |
| SCHEMBL168411 | 0.71 | MPO (0.54) | MPOCYP1A2CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL27393423 | 0.70 | RECQL (0.84) | RECQLMCL1CDK5MAPTCDK5R1 | |
| SCHEMBL8410920 | 0.70 | NPSR1 (0.68) | RECQLMCL1KDM4EALDH1A1GAA | |
| SCHEMBL28198401 | 0.69 | CDK1 (0.51) | CDK1KDM4EALDH1A1GAACDK2 | |
| SCHEMBL27686623 | 0.69 | CDK1 (0.47) | CDK1KDM4EALDH1A1GAACDK2 | |
| SCHEMBL7960340 | 0.69 | ALDH1A1 (0.38) | RECQLMCL1CDK1KDM4EALDH1A1 | |
| SCHEMBL1033545 | 0.68 | KMT2A (0.50) | RECQLMCL1CDK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2001517226-A | — | — | 2001-10-02 | — | — | JP | claimed |
| EP-0971925-A1 | PYRIMIDOPYRIMIDINE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2000-01-19 | — | — | EP | claimed |
| WO-1998043974-A1 | PYRIMIDOPYRIMIDINE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1998-10-08 | — | — | WO | claimed |