Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.30 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 2/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8561313 | 0.86 | HTR6 (0.31) | HTR2AHTR6CYP2D6 | |
| Hydrochloric Acid SCHEMBL30533389 | 0.83 | HTR2A (0.39) | HTR2AHTR6SIGMAR1KDM4ETP53 | |
| Hydrochloric Acid SCHEMBL29215999 | 0.79 | HTR2A (0.36) | HTR2AHTR6SIGMAR1KDM4ETP53 | |
| Hydrochloric Acid SCHEMBL647140 | 0.79 | HTR2A (0.36) | HTR2AHTR6SIGMAR1KDM4ETP53 | |
| Hydrochloric Acid SCHEMBL218233 | 0.79 | HTR2A (0.36) | HTR2AHTR6SIGMAR1KDM4ETP53 | |
| Hydrochloric Acid SCHEMBL6054094 | 0.78 | HTR2A (0.35) | HTR2AHTR6SIGMAR1KDM4ETP53 | |
| Hydrochloric Acid SCHEMBL30338416 | 0.76 | HTR2A (0.34) | HTR2AHTR6SIGMAR1 | |
| SCHEMBL7195752 | 0.75 | HTR2A (0.36) | HTR2AHTR6SIGMAR1KDM4ETP53 | |
| Hydrochloric Acid SCHEMBL273051 | 0.75 | HTR2A (0.33) | HTR2AHTR6SIGMAR1KDM4ETP53 | |
| Hydrochloric Acid SCHEMBL611048 | 0.75 | HTR2A (0.33) | HTR2AHTR6SIGMAR1KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001098380-A2 | PARTICULATE GROUP 4 METALLOCENE-ALUMINOXANE CATALYST COMPOSITIONS DEVOID OF PREFORMED SUPPORT, AND THEIR PREPARATION AND THEIR USE | ALBEMARLE CORPORATION (US) | 2001-12-27 | — | — | WO | disclosed |